Estimation of cancer mortality attributable to excess body weight during 2006–2015 in China |
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| Institution: | 1. Department of Public Health, and Department of Endocrinology of the Children''s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children’s Health, Hangzhou 310058, China;2. Department of Public Health, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;3. Department of Public Health, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;1. Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China;2. School of Public Health and Emergency Management, Southern University of Science and Technology, 1088 Xueyuan Street, Shenzhen 518055, China;1. Department of Plastic, and Breast Surgery, Aarhus University Hospital, Denmark;2. Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Denmark;3. Department of Plastic Surgery, Copenhagen University Hospital - Herlev and Gentofte, Denmark;4. Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Denmark;1. Brown School, Washington University in St. Louis, St. Louis, MO, USA;2. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA;3. Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA;4. Rollins School of Public Health, Emory University, Atlanta, GA, USA;1. Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark;2. Unit of Diet, Cancer and Health, Danish Cancer Society Research Center, Copenhagen, Denmark;3. Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark;4. Department of Gynecology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;1. Johns Hopkins Medicine, Department of Dermatology, Baltimore, MD, USA;2. University of Texas Southwestern Medical Center, Department of Dermatology, Dallas, TX, USA;3. Case Western Reserve University School of Medicine/University Hospitals Cleveland Medical Center, Department of Dermatology, Cleveland, OH, USA;1. Department of Clinical Laboratory, Sichuan Provincial Maternity and Child Health Care Hospital. The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, China;2. Department of Ultrasound, Sichuan Provincial Maternity and Child Health Care Hospital. The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, China;3. Department of Pathology, Sichuan Provincial Maternity and Child Health Care Hospital. The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, China;4. Chengdu Second People’s Hospital, Chengdu 610021, Sichuan, PR China;5. Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, Institute of Medical Genetics, College of Life Science, Sichuan University, China;6. Bio-resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Sichuan and Chongqing, China |
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| Abstract: | BackgroundCancer is one of the most common causes of death. Excess body weight (EBW), a risk factor for cancer, is highly prevalent in China. We aimed to estimate the number and proportion of cancer deaths attributed to EBW and their changes during 2006–2015 in China.MethodsPopulation attributable fractions in 2006, 2010, and 2015 were calculated with 1) prevalence of overweight/obesity, exacted from the China Health and Nutrition Survey conducted in 8–9 provinces of China in 1997, 2000, and 2004; 2) relative risks for EBW and site-specific cancers, obtained from previous studies; 3) data on cancer deaths in 2006, 2010, and 2015, originated from the Chinese Cancer Registry Annual Report.ResultsIn 2015, EBW contributed to 45,918 (3.1% of all) cancer deaths in China, with 24,978 (2.6%) in men and 20,940 (3.8%) in women. By region, the fraction of cancer deaths attributable to EBW ranged from 1.6% (West) to 4.1% (Northeast). Cancers of liver, stomach, and colorectum were the main EBW-attributable cancers. The fractions of cancer deaths attributable to EBW were 2.4% (95%CI: 0.8–4.2%) in 2006, 2.9% (95%CI: 1.0–5.2%) in 2010, and 3.1% (95%CI: 1.0–5.4%) in 2015, respectively, and increased for all gender, region, and cancer site during 2006–2015.ConclusionsThe proportion of cancer deaths attributed to EBW was higher in women and Northeastern China, with an upward trend in the recent decade. A combination of comprehensive and individualized measures is necessary to reduce the prevalence of EBW and related cancer burden in China. |
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| Keywords: | Excess body weight Population attributable fraction Cancer Mortality |
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