Iron deficiency and its epigenetic effects on iron homeostasis |
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| Institution: | 1. Department of Biochemistry and Molecular Biology, Faculty of Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;2. Department of Basic Medical and Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 13110, Jordan;3. Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;4. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;5. Department of Pharmacognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;6. Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;7. Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;8. Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University PMB, 2254 Sokoto, Nigeria;1. Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria;2. Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria;3. Departamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil;1. University of Western Brittany, LIEN, F-29200 Brest, France;2. Department of Dermatology, CHU Brest, Brest, France;3. LABOCEA, 120 avenue de Rochon, 29280 Plouzané, France;1. Servicio de Pediatría Hospital, Clínico San Carlos, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;2. Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;3. Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;4. Unidad de investigación. Servicio de Medicina Preventiva, Hospital Clínico San Carlos, Madrid, Spain;5. Hospital Universitario de la Zarzuela, Madrid, Spain;6. Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain;1. Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, Shanxi 030001, China;2. Key Lab of Environmental Hazard and Health of Shanxi Province, Shanxi Medical University, Taiyuan, Shanxi 030001, China;3. Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, Taiyuan, Shanxi 030001, China;4. Department of Anatomy, Shanxi Medical University, Taiyuan, Shanxi 030001, China |
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| Abstract: | Iron deficiency is a common micronutrient deficiency associated with metabolic changes in the levels of iron regulatory proteins, hepcidin and ferroportin. Studies have associated dysregulation of iron homeostasis to other secondary and life-threatening diseases including anaemia, neurodegeneration and metabolic diseases. Iron deficiency plays a critical role in epigenetic regulation by affecting the Fe2+/α-ketoglutarate-dependent demethylating enzymes, Ten Eleven Translocase 1–3 (TET 1–3) and Jumonji-C (JmjC) histone demethylase, which are involved in epigenetic erasure of the methylation marks on both DNA and histone tails, respectively. In this review, studies involving epigenetic effects of iron deficiency associated with dysregulation of TET 1–3 and JmjC histone demethylase enzyme activities on hepcidin/ferroportin axis are discussed. |
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| Keywords: | Iron deficiency Iron homeostasis Hepcidin Ferroportin Epigenetics Ten eleven translocase JmjC histone demethylase |
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