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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat
Affiliation:1. Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA;2. Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;3. Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Duke University, Durham, NC 27710, USA;4. Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;5. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA;6. Department of Biophysics and Biophysical Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA;1. Shenzhen Key Lab of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Center for Excellence in Brain Science and Intelligence Technology, the Brain Cognition and Brain Disease Institute, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;2. Department of Electrical Engineering, City University of Hong Kong, Hong Kong 999077, China;3. University of Science and Technology of China, Hefei 230026, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;1. VIB-KU Leuven Center for Brain & Disease Research, Leuven 3000, Belgium;2. KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven 3000, Belgium;3. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia Campus, Brisbane, QLD 4072, Australia;4. Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven 3000, Belgium;5. VIB-VUB Center for Structural Biology, Brussels 1050, Belgium;6. Department of Structural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium;7. KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven 3000, Belgium;8. Interdisciplinary Institute for Neuroscience, University of Bordeaux, F-33000 Bordeaux, France;9. VIB Bio Core, KU Leuven, Leuven 3000, Belgium;10. School of Biomedical Sciences, The University of Queensland, St Lucia Campus, Brisbane, QLD 4072, Australia;11. Univ. Bordeaux, CNRS UMR 5293, F-33000 Bordeaux, France;1. Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia;2. Institute for Biomedical Engineering, Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, 8057 Zurich, Switzerland;3. Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, 8093 Zurich, Switzerland;1. Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany;1. Laboratory of Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany;2. Centre for Nanomaterials and Biotechnology, Faculty of Science, Jan Evangelista Purkyne University, Usti nad Labem, Czech Republic;3. Department of Biology, Faculty of Science, Jan Evangelista Purkyne University, Usti nad Labem, Czech Republic;4. International Max Planck Research School for Brain and Behavior, Bonn, Germany;5. Institute of Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Planegg-Martinsried, Germany;6. Physiological Genomics, Biomedical Center, Ludwig-Maximilians University, Planegg-Martinsried, Germany;7. Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany;8. Ruđer Bošković Institute, Zagreb, Croatia;9. Excellence Cluster SyNergy, Biomedical Center, LMU, Planegg-Martinsried, Germany;1. VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium;2. KU Leuven Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium;3. UK Dementia Research Institute, London, UK
Abstract:
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