Correspondence regarding October 31, 2003, Breakthroughs and Views by K. Brown and P.L. Carmichael |
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Authors: | Sharma Minoti |
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Affiliation: | Department of Biotechnology, Faculty of Science, University of Tehran, Enghelab Ave., Tehran, Iran. marashie@khayam.ut.ac.ir |
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Abstract: | A. Fuglsang [Biochem. Biophys. Res. Commun. 317 (2004) 957-964] suggested that effective number of codons for individual amino acids (Nc-values) should be re-adjusted to the number of synonymous codons of those amino acids, in order to prevent the overestimation of the effective number of codons. Here, it is shown that re-adjustment at the level of individual amino acids results in loss of considerable amounts of information. Furthermore, we have shown that theoretical Nc-values are functions of GC3s (and GC1s); as a result, when an amino acid Nc-value exceeds the related theoretical Nc-value, the implication of re-adjustment depends on the GC composition of the gene. |
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Keywords: | Effective number of codons Nc Re-adjustment Codon usage bias |
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