The generation of hydroxyl radicals following superoxide production by neutrophil NADPH oxidase |
| |
| Authors: | J.V. Bannister P. Bellavite A. Davoli P.J. Thornalley F. Rossi |
| |
| Affiliation: | Inorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, England;Institute of General Pathology, University of Padova, Verona 37134, Italy |
| |
| Abstract: | Stimulated neutrophils generate superoxide and hydroxyl radicals. A membrane-bound NADPH oxidase, inactive in the resting state, is responsible for superoxide production. The production of hydroxyl radicals is through a secondary reaction. A Fenton-catalysed Haber—Weiss reaction is proposed. Transferrin was used as the catalyst in this investigation. |
| |
| Keywords: | Superoxide Hydroxyl radical Neutrophils NADPH oxidase Transferrin EPR |
| 本文献已被 ScienceDirect 等数据库收录！ |
