Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting |
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Authors: | Jimenez Maria Léger Bertrand Canola Kriss Lehr Lorenz Arboit Patrizia Seydoux Josiane Russell Aaron P Giacobino Jean Paul Muzzin Patrick Preitner Frédéric |
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Affiliation: | Département de Biochimie Médicale, Centre Médical Universitaire, 1, rue Michel-Servet, 1211 Genève 4, Switzerland. maria.jimenez@medecine.unige.ch |
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Abstract: | Catecholamines are viewed as major stimulants of diet- and cold-induced thermogenesis and of fasting-induced lipolysis, through the β-adrenoceptors (β1/β2/β3). To test this hypothesis, we generated β1/β2/β3-adrenoceptor triple knockout (TKO) mice and compared them to wild type animals. TKO mice exhibited normophagic obesity and cold-intolerance. Their brown fat had impaired morphology and lacked responses to cold of uncoupling protein-1 expression. In contrast, TKO mice had higher circulating levels of free fatty acids and glycerol at basal and fasted states, suggesting enhanced lipolysis. Hence, β-adrenergic signalling is essential for the resistance to obesity and cold, but not for the lipolytic response to fasting. |
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Keywords: | β-Adrenergic Obesity Uncoupling protein Fasting Thermogenesis |
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