Protective effect of hypothermia on brain neurons in rats exposed to ionizing radiation |
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| Authors: | R. Ya. Gordon D. A. Ignat’ev E. V. Mel’nikova V. V. Rogachevskii I. V. Kraev S. S. Khutsyan |
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| Affiliation: | (1) Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia |
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| Abstract: | The protein-synthesizing system of hippocampal (CA1, CA3) and sensorimotor cortex neurons is damaged less and recovers much quicker in rats exposed to 8 Gy of γ-radiation under hypoxia/hypercapnia (body temperature 16–18°C) than under usual conditions, as evidenced by microfluorimetry and electron microscopy. The radioprotective effect does not cover the membrane structures (endoplasmic reticulum and Golgi complex), and their restoration is not so prompt. |
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| Keywords: | hypothermia hypoxia/hypercapnia ionizing radiation protein-synthesizing system |
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