Yersinia pseudotuberculosis is resistant to killing by human neutrophils |
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| Authors: | Laws Thomas R Davey Martin S Green Christopher Cooper Ian A M Titball Richard W Lukaszewski Roman A |
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| Affiliation: | Defence Science and Technology Laboratory, Salisbury, Wiltshire SP4 OJQ, UK. trlaws@dstl.gov.uk |
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| Abstract: | The interaction between human neutrophils and the Gram negative gastrointestinal pathogen Yersinia pseudotuberculosis was investigated in vitro. Despite the wealth of data describing how Yersinia can affect the function of neutrophils, there are no published studies describing if neutrophil cells can affect the viability of Y. pseudotuberculosis. The wild-type IP32953 strain of Y. pseudotuberculosis was found to be resistant to killing by human neutrophils. Confocal examination and flow-cytometric analysis of this interaction revealed that bacteria were taken up. |
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