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Chromosomal banding patterns in human large bowel adenomas |
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| Authors: | Amelia Reichmann Paulette Martin B. Levin |
| Affiliation: | (1) Laboratoire de Biochimie Médicale associé au CNRS (LA 178), 27 Bd. Jean Moulin, F-13385 Marseille Cédex 5, France;(2) Unité 38 de l'INSERM, Faculté de Médecine, 27 Bd. Jean Moulin, F-13385 Marseille Cédex 5, France;(3) Centre de Génétique Médicale, Hôpital d'Enfants, La Timone, F-13385 Marseille Cédex 5, France;(4) Unité 242 de l'INSERM, Hôpital d'Enfants, La Timone, F-13385 Marseille Cédex 5, France |
| Abstract: | Summary The human thyroglobulin gene was mapped by in situ hybridization whereby a 3H-labeled recombinant plasmid DNA containing a fragment of 2.3 kilobases of human thyroglobulin gene was hybridized to human chromosome preparations. A high proportion (25%) of hybridized metaphases exhibited silver grains at the distal portion of the long arm of chromosome 8. Analysis of the grain position at this site indicated that the chromosomal localization of the human thyroglobulin gene was 8q242-8q243. |
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