Dispersible chitosan particles showing bacteriostatic effect against Streptococcus mutans and their dental polishing effect |
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Authors: | Kanako Saita Tomohiro Shirosaki Maki Horikawa Hirotaka Ihara |
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Institution: | 1. Kumamoto Industrial Research Institute, Kumamoto, Japansaita-k@kumamoto-iri.jp;3. Kumamoto Industrial Research Institute, Kumamoto, Japan;4. Department of Applied Chemistry &5. Biochemistry, Kumamoto University, Kumamoto, Japan |
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Abstract: | ABSTRACTNontoxic and biodegradable chitosan is potentially useful in various applications. We prepared submicron chitosan particles with high dispersibility in aqueous solution utilizing the electrostatic interaction phase separation method described in a previous report, but using citric acid as the polyvalent anionic compound instead of sodium sulfate. The submicron chitosan particles showed significant antibacterial activity and anti-adhesive action against Streptococcus mutans, even at around neutral pH. However, chitosan granules showed no antibacterial activity under the same conditions. The addition of the chitosan particles to dental polishing paste provided stainless steel discs (the same hardness as dental enamel) with a smoother surface than polishing paste without additives. In view of their submicron size and antibacterial activity, chitosan particles could potentially be multifunctional components of oral and dental cleaning materials. |
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Keywords: | Chitosan Streptococcus mutans antibacterial activity anti-adhesive action dental polishing paste |
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