New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793 |
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| Authors: | Teppei Kawahara Masashi Itoh Miho Izumikawa Noritaka Kagaya Noriaki Sakata Toshio Tsuchida |
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| Institution: | 1. Japan Biological Informatics Consortium (JBIC) , Tokyo, Japan  https://orcid.org/0000-0002-4702-0661;2. Research &3. Development Division, MicroBiopharm Japan Co., Ltd (MBJ) , Iwata, Japan;4. Japan Biological Informatics Consortium (JBIC) , Tokyo, Japan;5. National Institute of Advanced Industrial Science and Technology (AIST) , Tokyo, Japan |
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| Abstract: | ABSTRACT Chemical screening of culture medium from the soil fungus Stachybotrys sp. resulted in the isolation of the three new phenylspirodrimanes MBJ-0030 (1), MBJ-0031 (2) and MBJ-0032 (3). Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1–3 were determined by modified Mosher’s and Marfey’s methods. In addition, cytotoxic and antimicrobial evaluations of the compounds were conducted. |
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| Keywords: | Stachybotrys stachybotrin phenylspirodrimane |
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https://orcid.org/0000-0002-4702-0661;2. Research &3. Development Division, MicroBiopharm Japan Co., Ltd (MBJ) , Iwata, Japan;4. Japan Biological Informatics Consortium (JBIC) , Tokyo, Japan;5. National Institute of Advanced Industrial Science and Technology (AIST) , Tokyo, Japan