Effects of a pyroglutamyl pentapeptide isolated from fermented barley extract on atopic dermatitis-like skin lesions in hairless mouse |
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| Authors: | Naruyuki Maruoka Bunta Watanabe Daigo Ando Masahiro Miyashita Tatsuo Kurihara Hideki Hokazono |
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| Institution: | 1. Sanwa Shurui Co., Ltd ., Usa, Japan;2. Institute for Chemical Research, Kyoto University , Uji, Japan maruoka-n@kokuzo.co.jp;4. Institute for Chemical Research, Kyoto University , Uji, Japan;5. Graduate School of Agriculture, Kyoto University , Kyoto, Japan;6. Sanwa Shurui Co., Ltd ., Usa, Japan |
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| Abstract: | ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritic and eczematous skin lesions. The skin of AD patients is generally in a dried condition. Therefore, it is important for AD patients to manage skin moisturization. In this study, we examined the effects of orally administered fermented barley extract P (FBEP), which is prepared from a supernatant of barley shochu distillery by-product, on stratum corneum (SC) hydration and transepidermal water loss (TEWL) in AD-like lesions induced in hairless mice using 2,4,6-trinitrochlorobenzene. Oral administration of FBEP increased SC hydration and decreased TEWL in the dorsal skin of this mouse model. Further fractionation of FBEP showed that a pyroglutamyl pentapeptide, pEQPFP comprising all -L-form amino acids, is responsible for these activities. These results suggested that this pyroglutamyl pentapeptide may serve as a modality for the treatment of AD. |
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| Keywords: | Fermented barley extract pyroglutamyl pentapeptide atopic dermatitis stratum corneum hydration transepidermal water loss |
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