Intragastric administration of AMG517, a TRPV1 antagonist,enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice |
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Authors: | Jun Hai Kunitoshi Uchida Shotaro Nishimura Shoji Tabata |
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Institution: | 1. Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University , Fukuoka, Japan;2. Department of Physiological Science and Molecular Biology, Fukuoka Dental College , Fukuoka, Japan;3. Department of Physiological Science and Molecular Biology, Fukuoka Dental College , Fukuoka, Japan;4. Division of Environmental and Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka , Shizuoka, Japan;5. Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University , Fukuoka, Japan https://orcid.org/0000-0001-9347-6451;6. Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University , Fukuoka, Japan |
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Abstract: | ABSTRACT Transient receptor potential vanilloid 1 (TRPV1), a nociceptive cation channel, is known to play roles in regulating the energy metabolism (EM) of the whole body. We previously reported that TRPV1 antagonists such as AMG517 enhanced EM in mice, however, these mechanisms remain unclear. The aim of this study was to explore the mechanisms underlying the enhancement of EM by AMG517, a selective TRPV1 antagonist, in mice. Respiratory gas analysis indicated that intragastric administration of AMG517 enhanced EM along with increasing locomotor activity in mice. Next, to clarify the possible involvement with afferent sensory nerves, including the vagus, we desensitized the capsaicin-sensitive sensory nerves of mice by systemic capsaicin treatment. In the desensitized mice, intragastric administration of AMG517 did not change EM and locomotor activity. Therefore, this study indicated that intragastric administration of AMG517 enhanced EM and increased locomotor activity via capsaicin-sensitive sensory nerves, including vagal afferents in mice. |
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Keywords: | AMG517 capsaicin-sensitive sensory nerves energy metabolism locomotor activity |
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