Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress,inflammatory response,and apoptosis in rats |
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| Authors: | Yifan Tong Kaijie Wang Shuhai Sheng |
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| Institution: | 1. Department of Surgery, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China;2. Department of Breast Cancer Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, People’s Republic of China;3. Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan, Hebei, People’s Republic of China;4. Department of Breast Cancer Surgery, Tangshan Gongren Hospital, Tangshan, Hebei, People’s Republic of China |
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| Abstract: | ABSTRACTMost breast cancer survivors receiving chemotherapy have severe cognitive impairment, often referred to as “chemobrain.” Polydatin (PLD) is known to have many biological activities. Thus, this study aimed to determine whether symptoms of chemobrain can be prevented or relieved by PLD. The chemobrain models were established by intraperitoneal injection of doxorubicin (DOX, 2 mg/kg) in rats once a week for 4 weeks (DOX group and DOX+PLD group). In the PLD group and DOX+PLD group, PLD (50 mg/kg) was administered orally to rats every day. We found that PLD treatment significantly protected against DOX-induced learning and memory impairment, restored hippocampal histopathological architecture. Furthermore, PLD suppressed DOX-induced oxidative stress through up-regulating Nrf2, inhibited inflammatory response by activating the NF-κB pathway, and reduced hippocampal apoptosis. Therefore, the present study indicated that PLD offered neuroprotection against DOX-induced chemobrain. PLD may assist in preventing chemobrain after chemotherapy in patients with cancers. |
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| Keywords: | Chemobrain polydatin doxorubicin neuroprotection cognitive impairment |
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