Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production |
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| Authors: | Sanfu Lin Dianshan Ke Yinquan Lin Xiaomin Fu |
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| Affiliation: | 1. Department of Orthopedics, The Second Affiliated Hospital of Fujian Medical University , Quanzhou, Fujian, China;2. Department of Orthopedics, The People’s Hospital of JiangMen , Jiangmen, Guangdong, China;3. Division of Metabolism and Endocrinology, John Hopkins University , Baltimore, MD, USA |
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| Abstract: | ABSTRACT Puerarin inhibits osteoclastogenesis and cells migration. This study aims to explore whether puerarin prevents osteoclastogenesis by inhibiting osteoclast precursors (OCPs) migration. The results showed that puerarin reduced MCP-1 production in OCPs, while inhibiting OCPs migration based on MCP-1. Puerarin reversed MCP-1-promoted osteoclastogenesis. CCR2 overexpression didn’t increase osteoclastogenesis with puerarin. Therefore, puerarin prevents OCPs migration by reducing MCP-1, whereby inhibiting osteoclastogenesis. |
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| Keywords: | Puerarin osteoclast osteoclast precursors migration MCP-1 |
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