Hizikia fusiforme extract enhances dendritic cell maturation in vitro and in vivo |
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Authors: | Mi Eun Kim Jun Hwi Cho Inae Jung Hyung Keun Kim |
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Affiliation: | 1. Department of Life Science, Immunology Research Lab, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University , Gwangju, Republic of Korea;2. Department of Orthopaedics Surgery, Korea Biomedical Materials and Devices Innovation Research Center of Chonnam National University Hospital , Gwangju, Republic of Korea |
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Abstract: | ABSTRACT Dendritic cells (DCs) are play critical roles in the priming and regulation of immune responses. DCs rapidly process and convey these antigens to prime antigen-specific T cells. Therefore, regulation of DCs functions is important for immunity and immunotherapies. Immune adjuvants for DCs activation are needed to improve the efficacy of vaccines against tumors and many infectious diseases. Therefore, we demonstrate that H. fusiformis extract can regulate DCs maturation and activation. H. fusiformis extract induced costimulatory molecules (CD 80 and CD86), antigen-presenting molecules (major histocompatibility complex (MHC) I and II), CCR7 expression, and interleukin (IL)-12 production in DCs. These effects are associated with upregulation of mitogen-activated protein kinase (MAPK) signaling pathway. In addition, H. fusiformis extract induces costimulatory molecules on splenic DCs and activated CD8+ T cells in vivo. Taken together, these findings suggest that H. fusiformis extract may be a potential efficient immune therapeutic compound in DCs-mediated immunotherapies. |
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Keywords: | H. fusiformis dendritic cells DC-mediated immunotherapy |
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