蛋白磷酸化与两组分信号系统

可逆的蛋白磷酸化是生物体内存在的一种最为普遍的调节方式,几乎涉及所有的生理及病理过程,在细胞的信号传递中起着极其重要的作用。根据底物蛋白质被磷酸化的氨基酸种类可将各种蛋白激酶分为3类:第一类为丝氨酸/苏氨酸蛋白激酶(ｓｅｒｉｎｅｔｈｒｅｏｎｉｎｅｐｒｏｔｅｉｎｋｉｎａｓｅ,ＳＰＫ),目前发现的蛋白激酶多属此类;第二类为酪氨酸蛋白激酶(ｔｙｒｏｓｉｎｅｐｒｏｔｅｉｎｋｉｎａｓｅ,ＴＰＫ),这类激...

Protein Phosphorylation and Two-component System

Reversible protein phosphorylation is the most widely used mechanism to regulate various physiological and pathological processes.Two|component system,which characterized by histidine phosphorylation,plays important roles in adaptation to environment,initiation of sporulation and other processes in prokaryotes.Current research reveals that this ancient signal transduction mechanism also exists in eukaryote such as fungus,slime mold and plants,in which it regulates the osmolarity and hormone signal transduction.However,two|component system in eukaryote is not only more complicated in organization pattern but also differs in biochemical mechanism when compared with that in prokaryote.This article explains the basic principal and physiological function of two|component system by comparing the examples in prokaryotic and eukaryotic organisms with the results obtained in our laboratory.