Cell type-specific dendritic polarity in the absence of spatially organized external cues |
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| Authors: | April C Horton Jason J Yi Michael D Ehlers |
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| Institution: | (1) Department of Neurobiology, Durham, NC 27710, USA;(2) Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA;(3) Howard Hughes Medical Institute, Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA |
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| Abstract: | Pyramidal neurons of the hippocampus and cortex have polarized dendritic arbors, but little is known about the cellular mechanisms
distinguishing apical and basal dendrites. We used morphometric analysis and time lapse imaging of cultured hippocampal neurons
to show that glutamatergic neurons develop progressive dendritic asymmetry in the absence of polarized extrinsic cues. Thus,
pyramidal neurons have a cellular program for polarized dendrite growth independent of tissue microenvironment. |
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