大鼠侧脑室注射神经降压素对血压的作用

雄性Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠,用乌拉坦腹腔麻醉,在侧脑室注射神经降压素（ＮＴ）（１０,２０μｇ）可引起血压升高或降低,心率减慢,预先ｉｃｖ ａ１受体阻断剂哌唑嗪,可阻断ＮＴ的中枢升压反应,预先ｉｃｖ Ｍ受体阻断剂硫酸阿托品,可阻断ＮＴ的中枢降压反应,预先ｉｃｖ Ｈ１受体阻断剂扑尔敏或Ｈ２受体阻断剂甲氰咪胍,对ＮＴ的中枢心血管效应均无明显影响。实验结果表明：脑中ＮＴ升高可使血压升高或降低;在

Effect of intracerebroventricular neurotensin injection on blood pressure in rat

Injection of neurotensin (NT) (10 and 20 g/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (12 g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with 1receptor blocker prazosin (15 g/3 l, icv) and M receptor blocker atropine (25 g/3 l, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H1 receptor blocker chlorpheniramin (50 g/3 l, icv ) or H2 receptor blocker cimetidine (250 g/3 l, icv). In view of the above results it appears that NT, catecholamine and acetylcholine are all involved in central regulation of blood pressure.