Melanin Biosynthesis in Cryptococcus neoformans |
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| Authors: | Peter R. Williamson Kazumasa Wakamatsu Shosuke Ito |
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| Affiliation: | Division of Infectious Diseases, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612,1. and Fujita Health University School of Health Sciences, Toyoake, Aichi 470-1192, Japan2. |
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| Abstract: | Pigment production by Cryptococcus neoformans is virulence associated. Dopamine- and 3,4-dihydroxyphenylalanine–melanin products were identified after acidic permanganate oxidation, alkaline hydrogen peroxide oxidation, or hydrolysis with hydriodic acid. These data provide direct chemical evidence for the formation of eumelanin polymers by catecholamine oxidation by laccase alone followed by oxidative coupling of dihydroxyindole. |
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