Molecular dynamics simulation of dipalmitoylphosphatidylserine bilayer with Na+ counterions |
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Authors: | Pandit Sagar A Berkowitz Max L |
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Institution: | Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA. |
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Abstract: | We performed a molecular dynamics simulation of dipalmitoylphosphatidylserine (DPPS) bilayer with Na+ counterions. We found that hydrogen bonding between the NH group and the phosphate group leads to a reduction in the area per headgroup when compared to the area in dipalmitoylphosphatidylcholine bilayer. The Na+ ions bind to the oxygen in the carboxyl group of serine, thus giving rise to a dipolar bilayer similar to dipalmitoylphosphatidylethanolamine bilayer. The results of the simulation show that counterions play a crucial role in determining the structural and electrostatic properties of DPPS bilayer. |
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