A new catalytic function of halohydrin hydrogen-halide-lyase, synthesis of beta-hydroxynitriles from epoxides and cyanide. |
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| Authors: | T Nakamura T Nagasawa F Yu I Watanabe H Yamada |
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| Affiliation: | Central Research Laboratory, Nitto Chemical Industry Co., Ltd., Yokohama, Japan. |
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| Abstract: | Halohydrin hydrogen-halide-lyase, which catalyzes the interconversion of halohydrins to epoxides, purified from a recombinant E. coli was found to catalyze the transformation of 1,2-epoxybutane into beta-hydroxyvaleronitrile in the presence of cyanide. Chloride inhibited competitively the formation of beta-hydroxyvaleronitrile. The enzyme also catalyzed the transformation of some other epoxides into the corresponding beta-hydroxynitriles in the presence of cyanide. |
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