Pertactin antigens extracted from Bordetella pertussis and Bordetella bronchiseptica differ in the isoelectric point |
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Authors: | Cristina Pagliaccia Roberto Manetti R. Rappuoli |
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Affiliation: | (1) IRIS, The Chiron Vaccines Immunobiological Research Institute, Via Fiorentina 1, 53100 Siena, Italy Tel. +39-577-243414; Fax +39-577-243564 email: rappuoli@iris02.biocine.it, IT |
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Abstract: | Pertactin, which is a membrane-associated antigen of Bordetella pertussis and which is present in many acellular vaccines against whooping cough, has been reported to be similar to the homologous protein in Bordetella bronchiseptica. By running parallel experiments using proteins derived from the two species, we show that the isoelectric point of pertactin from B. pertussis is lower than reported and clearly distinguishable from the homologous protein of B. bronchiseptica. Received: 9 April 1997 / Accepted: 20 May 1997 |
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Keywords: | Pertactin 69K antigen Bordetella pertussis Bordetella bronchiseptica Pertussis vaccine Acellular pertussis vaccine |
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