A tripeptide discriminator for stop codon recognition |
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| Authors: | Nakamura Yoshikazu Ito Koichi |
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| Institution: | Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8630, Tokyo, Japan. nak@ims.u-tokyo.ac.jp |
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| Abstract: | Only recently has it been established that a tripeptide in the bacterial release factors (RFs), RF1 and RF2, is responsible for the stop codon recognition. This functional mimic of the anticodon of tRNA is referred to as a tripeptide 'anticodon' or a tripeptide discriminator. Here we review the experimental background and process leading to this discovery, and strengthen functional evidence for the tripeptide determinant for deciphering stop codons in mRNAs in prokaryotes. |
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| Keywords: | Translation termination Stop codon Tripeptide anticodon Polypeptide release factor tRNA mimic |
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