X-ray observations on a collagen fibril lattice structure in peripheral nerve |
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Authors: | Hideyo Inouye C.R. Worthington |
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Affiliation: | Department of Biological Sciences, Carnegie-Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA |
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Abstract: | It has been known for more than two decades that peripheral nerve shows X-ray reflections other than those originating from the myelin sheath. These extra reflections are at small angles of diffraction and arise from a variation of electron density in the radial direction. X-ray diffraction studies since 1973 have identified these reflections as coming from a lattice structure of filaments, the filament axes are parallel to the nerve fibre axis. The present X-ray observations were obtained using a high-resolution X-ray camera and we conclude that these reflections arise from a collagen fibril lattice structure within peripheral nerve. Estimates of fibril radius and the separation distance between fibrils in intact rat, rabbit and frog sciatic nerves have been obtained using X-ray analysis. |
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Keywords: | X-ray diffraction analysis peripheral nerve collagen fibrils lattice structure model calculations |
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