Relaxation time measurements of hyaluronic acid |
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| Authors: | H Hofmann O Schmut H Sterk H Pölzler |
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| Institution: | 1. Universitäts-Augenklinik Graz Auenbruggerplatz 4, 8036 Graz, Austria;2. Institut für Organische Chemie, Universität Graz, Heinrichstrase 28, 8020 Graz, Austria |
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| Abstract: | The N-acetyl-groups of hyaluronic acid and its sodium salts are shown to have pH-dependent T1, T2 and NOE values, unlike all other carbonatoms and protons. This behaviour at high temperatures can be explained by assuming that parts of the helical structure are converted into random coil by H-bond breaking. Moreover, the concentration of Na+, Mg2+, or Ca2+ is shown to have no influence on the relaxational behaviour of HA. |
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| Keywords: | Polysaccharides hyaluronic acid relaxation time measurements molecular mobility |
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