Conformational basis of N-glycosylation of proteins: conformational analysis of Ac-Asn-Ala-Thr-NH2 |
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| Authors: | JM Ricart JJ Pérez M Pons E Giralt |
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| Institution: | 1. Departament de Química Física, Facultat de Química, Universitat de Barcelona, Avda. Diagonal, 645 Barcelona 28, Spain;2. Department de Química Orgànica, Facultat de Química, Universitat de Barcelona, Avda. Diagonal, 645 Barcelona 28, Spain |
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| Abstract: | The structural requirements of the Asn-X-Thr(Ser) sequence for the N-glycosylation of proteins has been traced to a local conformation acting as a signal for the enzymatic process. The conformational space of the smallest in vivoN-glycosylation substrate, Ac-Asn-Ala-Thr-NH2, has been thoroughly explored using energy calculations. All the lowest energy conformers have been characterized as bended structures. |
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| Keywords: | Energy calculations hydrogen bond peptide conformation |
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