Stress enhanced calcium kinetics in a neuron |
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Authors: | Aayush Kant Tanmay K Bhandakkar Nikhil V Medhekar |
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Institution: | 1.Department of Material Science and Engineering,Monash University,Victoria,Australia;2.Department of Mechanical Engineering,Indian Institute of Technology Bombay,Powai, Mumbai,India;3.IITB-Monash Research Academy,IIT Bombay,Powai, Mumbai,India |
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Abstract: | Accurate modeling of the mechanobiological response of a Traumatic Brain Injury is beneficial toward its effective clinical examination, treatment and prevention. Here, we present a stress history-dependent non-spatial kinetic model to predict the microscale phenomena of secondary insults due to accumulation of excess calcium ions (Ca\(^{2+}\)) induced by the macroscale primary injuries. The model is able to capture the experimentally observed increase and subsequent partial recovery of intracellular Ca\(^{2+}\) concentration in response to various types of mechanical impulses. We further establish the accuracy of the model by comparing our predictions with key experimental observations. |
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