Nox和氧化应激与糖尿病

Nox(phagocyte-like NADPH oxidase)是吞噬细胞NADPH氧化酶催化亚基 gp91phox的一系列同源物，广泛分布于体内多种非吞噬细胞.与NADPH氧化酶类似， Nox激活后可产生ROS，Nox产生的ROS是线粒体外ROS的主要来源.Nox产生的ROS，在控制新陈代谢，调节葡萄糖刺激的胰岛素分泌(glucose-stimulated insulin secretion，GSIS)，促使胰岛β细胞凋亡、胰岛功能障碍和糖尿病及其并发症的发 生、发展中，发挥着重要作用.调节Nox的活性，改善机体内氧化应激水平，有望成为治疗糖尿病及其并发症的有效新途径.

Nox and Oxidative Stress in Diabetes

Nox(phagocytel-ike NADPH oxidase) is the homologs of gp91phox which is the catalytic subunit of the NADPH oxidase. Nox widely exists in various non-phagocytic cells.Like NADPH oxidase，Nox has the ability to generate ROS.ROS derived from Nox，is the major source of extra- mitochondrial ROS in the body.Nox plays a crucial role in many pathological and physiological processes，like regulating metabolism，adjusting GSIS(glucose-stimulated insulin secretion，GSIS)，promoting islet dysfunction，inducing pancreatic β-cell apoptosis，resulting in diabetes and diabetic complications.Modulating the oxidative stress status through regulating Nox activity，is expected to be a new effective way to treat diabetes and diabetic complications.