Pregnancy failure in hypophysectomized rats following LH-RH administration. |
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| Authors: | G J Macdonald C W Beattie |
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| Institution: | 1. Department of Anatomy, CMDNJ-Rutgers Medicals School Piscataway, New Jersey 08854 USA;2. Department of Surgery University of Illinois at the Medical Center Chicago, Illinois 60680 USA |
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| Abstract: | Daily LH-RH administration induced a dose related increase in fetal resorption in rats following hypophysectomy on Day 11 or Day 12 of pregnancy. Ovarian and adrenal weights, as well as serum progesterone levels, were significantly decreased by Day 18. Serum progesterone was also significantly lower than control in those animals that remained pregnant after receiving LH-RH post-hypophysectomy. These observations suggest that LH-RH exerts an anti-pregnancy effect via a placental:ovarian axis in this species. |
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