RNA-dependent DNA polymerase: presence in normal human cells |
| |
| Authors: | P E Penner L H Cohen L A Loeb |
| |
| Affiliation: | 1. Innovative Public Health and Development, Harare, Zimbabwe;2. Department of Biological Sciences and Ecology, University of Zimbabwe;3. University of Kwazulu Natal, Durban, South Africa;4. ICAP at Columbia University, Lusaka, Zambia;5. Ministry of Health and Child Care, Harare, Zimbabwe;6. National AIDS Council, Harare Zimbabwe;7. International Initiative for Impact Evaluation, Harare, Zimbabwe;1. The Centre for HIV and AIDS Prevention Studies, Windhoek, Namibia;2. University of Kwa-Zulu Natal, College of Health Sciences, School of Nursing & Public Health, Durban, South Africa;3. Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe;4. Medical Centre Oshakati, Oshakati, Namibia;5. School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa |
| |
| Abstract: | RNA-dependent DNA polymerase has been reported in oncogenic RNA viruses, as well as in human leukemia cells, suggesting a close relationship between this activity and malignancy. However, we have detected an RNA-dependent DNA polymerase activity in normal human lymphocytes stimulated with phytohemagglutinin, indicating either that this enzyme is not unique to RNA-viruses, or that a viral genome is present in non-malignant human cells. Therefore, the use of this activity as an indication of malignancy or a target for the control of cancer should be approached with caution. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
