| 低压低氧对胎鼠海马神经元NMDA受体影响的实验研究 |
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| 引用本文： | Huang H,Ruan HZ,Fan XT. 低压低氧对胎鼠海马神经元NMDA受体影响的实验研究[J]. 中国应用生理学杂志, 2002, 18(4): 321-323 |
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| 作者姓名： | Huang H Ruan HZ Fan XT |
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| 作者单位： | 第三军医大学神经生物学教研室,重庆,400038 |
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| 基金项目： | 军队九五医药卫生课题 (98M 0 89) |
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| 摘 要： | 目的：观察低压低氧环境对胎鼠海马神经元NMDA受体数目和通道特性的影响。方法：采用原位杂交和膜片钳观察NMDA受体的数量和功能。结果：胎鼠低压低氧后,NMDA受体数量和通道开放机率减少,通道开放时间常数减少,通道关闭时间常数增加。结论：低压低氧影响到胎鼠NMDA受体的发育,提示低压低氧环境下大鼠的学习记忆可能受到影响。
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| 关 键 词： | 低压低氧 胎鼠 海马神经元 NMDA受体 影响 实验研究 原位杂交 膜片钳 高原 |
| 文章编号： | 1000-6834(2002)04-0321-03 |
| 修稿时间： | 2001-09-29 |
Effect of fetus hypobaric hypoxia on NMDA receptor of hippocampus neurons |
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| Huang Hui,Ruan Huai-zhen,Fan Xiao-tang. Effect of fetus hypobaric hypoxia on NMDA receptor of hippocampus neurons[J]. Chinese journal of applied physiology, 2002, 18(4): 321-323 |
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| Authors: | Huang Hui Ruan Huai-zhen Fan Xiao-tang |
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| Affiliation: | HUANG Hui,RUAN Huai zhen,FAN Xiao tang,et al . |
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| Abstract: | Aim: To study the effect of fetus hypobaric hypoxia on the number and channel character of NMDA receptor of hippocampus neurons. Methods: Use in situ hybridization and patch clamp techniques. Results: After hypobaric hypoxia the number of NMDA mRNA positive neurons was decreased, the open probability of NMDA receptor was reduced, the open time constant was decreased,the close time constant was increased. Conclusion: Hypobaric hypoxia may change the development of NMDA receptor in fetus rat, then maybe effect learning and memory. |
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| Keywords: | hypobaric hypoxia in situ hybridization patch clamp NMDA receptor |
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