| 乳酸乳球菌表达系统的发展现状与前景展望 |
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| 引用本文： | 高莹,李淼,孙元,单春华,仇华吉.乳酸乳球菌表达系统的发展现状与前景展望[J].微生物学报,2022,62(3):895-905. |
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| 作者姓名： | 高莹 李淼 孙元 单春华 仇华吉 |
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| 作者单位： | 东北林业大学生命科学学院, 黑龙江 哈尔滨 150040;中国农业科学院哈尔滨兽医研究所, 兽医生物技术国家重点实验室, 黑龙江 哈尔滨 150069 |
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| 基金项目： | 国家自然科学基金（31802169） |
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| 摘 要： | 乳酸乳球菌作为全球公认安全的微生物,具有多种益生作用,常被用作基因工程宿主菌.在过去的二十年中,乳酸乳球菌作为载体在递呈病毒、细菌抗原等方面得到了广泛的应用,并且在不同领域发挥着重要作用.本文以乳链菌肽控制的表达(nisin-controlled expression,NICE)系统为例,介绍了基于乳酸乳球菌的表达系统...
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| 关 键 词： | 乳酸乳球菌 宿主菌 乳链菌肽控制的系统 应用 |
| 收稿时间： | 2021/6/12 0:00:00 |
| 修稿时间： | 2021/9/9 0:00:00 |
Development and prospects of Lactococcus lactis expression system |
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| GAO Ying,LI Miao,SUN Yuan,SHAN Chunhu,QIU Huaji.Development and prospects of Lactococcus lactis expression system[J].Acta Microbiologica Sinica,2022,62(3):895-905. |
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| Authors: | GAO Ying LI Miao SUN Yuan SHAN Chunhu QIU Huaji |
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| Institution: | College of Life Science, Northeast Forestry University, Harbin 150040, Heilongjiang, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, Heilongjiang, China |
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| Abstract: | Lactococcus lactis has a variety of probiotic effects and is often used as a host strain for genetic engineering. It is generally recognized as safe (GRAS) by the Food and Drug Administration (FDA). In the past two decades, L. lactis has been widely used as a carrier in presenting viruses and bacterial antigens, playing an important role in different fields. In this review, we introduced the nisin-controlled expression (NICE) system from the aspects of composition, functional characteristics, and the application in food, vaccines, animal husbandry, and veterinary medicine. We summarized the features and improvements and then predicted the development prospects of NICE system. |
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| Keywords: | Lactococcus lactis host bacteria nisin-controlled expression system (NICE) application |
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