Relationship Between Virus-Induced Cellular Deoxyribonucleic Acid Synthesis and Transformation by Simian Virus 40 |
| |
| Authors: | Thomas O. Fox and Arnold J. Levine |
| |
| Affiliation: | Department of Biochemistry, Princeton University, Princeton, New Jersey 08540 |
| |
| Abstract: | The fraction of cells in a confluent 3T3 cell monolayer induced by simian virus 40 infection to replicate deoxyribonucleic acid and divide corresponds to those cells which eventually become transformed. Virus-induced cells were partially separated from noninduced cells by sedimentation through Ficoll gradients. Three- to eightfold higher transformation frequencies were obtained with those cells that began to synthesize cellular deoxyribonucleic acid and divide shortly after simian virus 40 infection as compared to noninduced cells. |
| |
| Keywords: | |
|
