Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system |
| |
| Institution: | 1. Discovery BiologyTarget GenomicsPfizer, Sandwich, Kent UK CT13 9NJ;2. Clinical Pharmacology Unit University of Cambridge, Box 110, Centre for Clinical Investigation Addenbrooke''s Hospital UK CB2 2QQ;1. Department of Microbiology, Faculty of Veterinary Medicine, Erciyes University, 38280 Kayseri, Turkey;2. Department of Aquatic Animal Diseases, Faculty of Veterinary Medicine, Erciyes University, 38280 Kayseri, Turkey;3. Department of Molecular Biology and Genetics, Faculty of Science and Arts, Ondokuz Mayis University, 55139 Samsun, Turkey;4. Medical Microbiology Clinic, Şişli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, 34371 Istanbul, Turkey;1. Centre de Biotechnologies Végétale et Microbienne, Biodiversité et Environnement, Faculté des Sciences, Université Mohammed V de Rabat, 4, Avenue Ibn Battouta, Rabat, Morocco;2. Departamento de Microbiología del Suelo y Sistemas Simbióticos Estación Experimental del Zaidín, CSIC Apartado Postal 419, 18080 Granada, Spain;1. Institute of Materials Science and Technology, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria;2. Christian Doppler Laboratory for Interfaces and Precipitation Engineering (CDL-IPE), Institute of Materials Science and Technology, TU Wien, Getreidemarkt 9, 1060 Vienna, Austria;3. Oerlikon Balzers, Oerlikon Surface Solutions AG, Iramalli 18, 9496 Balzers, Liechtenstein;4. OC Oerlikon Management AG, 8808 Pfäffikon SZ, Switzerland;1. College of Pharmacy, Qiqihar Medical University, Qiqihar, 161006, PR China;2. Scientific Research Department, Qiqihar Medical University, Qiqihar, 161006, PR China;3. Research Institute of Medicine & Pharmacy, Qiqihar Medical University, Qiqihar, 161006, PR China;1. Winogradsky Institute of Microbiology, Research Centre of Biotechnology, Russian Academy of Sciences, Moscow, Russia;2. Department of Biotechnology, Section of Environmental Biotechnology, TU Delft, The Netherlands;3. Institute of Polar Research, ISP-CNR, Messina, Italy;4. IAMC-CNR, Messina, Italy;5. NIOZ Royal Netherlands Institute for Sea Research, Department of Marine Microbiology and Biogeochemistry, and Utrecht University, Utrecht, The Netherlands |
| |
| Abstract: | Despite current drug therapies, including those that target enzymes, channels and known G-protein-coupled receptors (GPCRs), cardiovascular disease remains the major cause of ill health, which suggests that other transmitter systems might be involved in this disease. In humans, ∼175 genes have been predicted to encode ‘orphan’ GPCRs, where the endogenous ligand is not yet known. As a result of intensive screening using ‘reverse pharmacology’, an increasing number of orphan receptors are being paired with their cognate ligands, many of which are peptides. The existence of some of these peptides such as urotensin-II and relaxin had been known for some time but others, including ghrelin and apelin, represent novel sequences. The pharmacological characterization of these emerging peptide–receptor systems is a tantalising area of cardiovascular research, with the prospect of identifying new therapeutic targets. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
