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Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat |
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| Authors: | L Galzigna M Bianchi V Rizzoli R Scuri P Giannetti A Paesano |
| Affiliation: | Department of Biological Chemistry, University of Padova, Italy. |
| Abstract: | Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP. |
| Keywords: | Fructose-1, 6-diphosphate (FDP) heart slices GABA-receptors Ca++ entry Cl− up-take gastric ulcers serum transaminases diuresis narcosis dependence and withdrawal symptoms |