Activation and migration of allo-peptide specific TCR transgenic T cells in cardiac allograft rejection |
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Authors: | Honjo Kazuhito Xu Xiao Yan Kapp Judith A Bucy R Pat |
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Institution: | Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233-7331, USA. |
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Abstract: | T cells from TCR transgenic mice, expressing receptors specific for an allogeneic MHC class I peptide, were used to track T cell activation and migration in normal adoptive recipients that were subsequently transplanted with heterotopic hearts that were syngeneic except for a transgenic MHC class I antigen. T cells rapidly disappeared from the blood into the lymphoid tissues where they were activated within one day after transplantation. T cells initially formed discrete clusters in the spleen and lymph nodes. After proliferating for 2-4 days in lymphoid tissues, T cells reappeared in the blood and migrated to the heart and the intestines. The T cells underwent another round of proliferation in the heart, but not the intestines, and induced cardiac rejection uniformly on 6 day. |
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Keywords: | TCR transgenic Allograft rejection T cell dynamics Heart transplantation Morphometric analysis |
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