Synthesis and characterization of water-soluble two-photon excited blue fluorescent chromophores for bioimaging. |
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| Authors: | Ali Hayek Frédéric Bolze Jean-Fran?ois Nicoud Patrice L Baldeck Yves Mély |
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| Affiliation: | Groupe des Matériaux Organiques, Institut de Physique et Chimie des Matériaux de Strasbourg, CNRS, 23 rue du Loess, F-67034, Strasbourg, France. |
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| Abstract: | We report here the synthesis and characterization of a new type of non-ionic blue fluorescent water-soluble chromophores specifically designed for two-photon absorption microscopy. The water solubility is induced by introduction of short oligo(ethylene glycol) monomethyl ether moieties. This work has led to low molecular weight dyes with efficient two-photon absorption cross sections and high fluorescence quantum yield in organic solvents as well as in aqueous solutions. |
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