Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum |
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| Authors: | Nissanka A P Karunaratne V Bandara B M Kumar V Nakanishi T Nishi M Inada A Tillekeratne L M Wijesundara D S Gunatilaka A A |
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| Affiliation: | Department of Chemistry, University of Peradeniya, Sri Lanka. |
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| Abstract: | Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity. |
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