Wheat germ lipase catalyzed kinetic resolution of secondary alcohols in non-aqueous media |
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| Authors: | Xiaole Xia Yong-Hua Wang Bo Yang Xiaoning Wang |
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| Institution: | (1) School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, 510006, China;(2) College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, 510641, China |
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| Abstract: | The lipase from wheat germ was used for the kinetic resolution of secondary alcohols. It has the opposite enantioselectivity
against the Kazlauskas rule and acts as an anti-Kazlauskas catalyst. The effect of initial water activity, organic solvent,
acyl donor and temperature were investigated. Wheat germ lipase had a high activity and enantioselectivity only in n-hexane with a high initial water activity (αw = 0.97), especially with 1-phenylethanol (C 32%, E > 200). Its performance changed little with the chain length of acyl donor and temperature.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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| Keywords: | Anti-Kazlauskas catalyst Kinetic resolution Lipase Secondary alcohol Wheat germ lipase |
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