Genetics of 51d-52a, a Region Containing Several Maternal-Effect Genes and Two Maternal-Specific Transcripts in Drosophila |
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Authors: | E. M. Underwood A. S. Briot K. Z. Doll R. L. Ludwiczak D. C. Otteson J. Tower K. B. Vessey K. Yu |
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Affiliation: | Department of Biological Sciences, Bowling Green State University, Ohio 43403. |
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Abstract: | Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-sterile and lethal mutations isolated. A total of twelve complementation groups have been identified, four of which are defined exclusively by female-sterile alleles. Only one visible mutation was isolated, a recessive temperature-sensitive allele of Thickened-arista (Tarts). Several of the seven lethal loci display an embryonic lethal phase. Three of the four female-sterile loci affect chorion structure with one resulting in underamplification of the chorion genes, and two (possibly three) of the four female-steriles affect nuclear division/DNA replication. Thus it appears that this is a "developmentally important" region, possibly representing a clustering of genes involved in either DNA replication or nuclear division. |
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