3H]spiroperidol binding on lymphocytes: changes in two different groups of schizophrenic patients and effect of neuroleptic treatment |
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Authors: | G Le Fur E Zarifian T Phan H Cuche A Flamier F Bouchami M C Burgevin H Loo A Gérard A Uzan |
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Affiliation: | 1. Laboratoires PHARMUKA, 35, quai du Moulin de Cage, F 92231 Gennevilliers, France;1. Hôspital Sainte-Anne, 1, rue Cabanis, F 75014 Paris, France |
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Abstract: | [3H]spiroperidol binding to lymphocytes was measured in untreated paranoid or disorganized and treated paranoid schizophrenic patients. An increase in the Bmax was detected in untreated paranoid patients but a decrease was found in the disorganized patients. No difference was detected in the KD value. Neuroleptic treatment produced a decrease in the Bmax without affecting the KD value. Such results did not comply with the down regulation but might be explained by a change in membrane viscosity as [3H]spiroperidol binding sites on lymphocytes were coupled to phospholipid methylation. |
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