112株志贺菌菌群分布和药敏特点分析

目的研究本地区2001年至2005年志贺菌菌群分布及其药敏特点,以指导临床合理抗菌治疗。方法经大便培养筛选志贺菌,用生化和血清学方法鉴定菌群和血清型,采用K-B法检测病原菌耐药性。结果在112例细菌性痢疾患者中,男女比例相似,年龄分布以婴幼儿最高,临床表现不典型者较多,菌群分布以福氏志贺菌最多,F2b为优势血清型,对抗菌药物敏感性差异有显著性。结论近5年来本地区细菌性痢疾患者发病特点有年龄差异,菌群仍以福氏志贺菌为主,血清型以F2b为主,第3代头孢菌素是治疗细菌性痢疾最佳的抗菌药物。

Analysis of the distribution and the rate of drug sensitivity of 112 strains of Shigella bacteria

Objective To investigate the distribution and the rate of drug sensitivity with actue bacillary dysentery in our area between 2001~2005 so as to guide the choice of antibiotics.Methods Shigella bacteria were cultured from stool and serotype were identified with the biochemical and serologic methods.The drug sensitive rate was tested with Kirby-Bauer method.Results Among 112 patients with shigellosis the incidence rate in male was similar to the one in female cases and children had the most incidence,the clinical characteristic was more atypical.Shigella flexneri was the dominant serotype and F2b was the dominant group.There was different in drug sensitivity test.Conclusions Shigella flexnri was the dominant group in 112 strains of Shigella in our area between 2001~2005,and F2b was the dominant serotype among Shigella flexneri.For antibiotics,third generation cephalosporin was the most active drug but have to be used rationally.