Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12 |
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Authors: | Xu Jianfeng Bleecker Eugene R Jongepier Hajo Howard Timothy D Koppelman Gerard H Postma Dirkje S Meyers Deborah A |
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Institution: | Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. jxu@wfubmc.edu |
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Abstract: | Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits. |
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