Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents |
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| Authors: | Agarwal Anu Srivastava Kumkum Puri S K Chauhan Prem M S |
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| Institution: | Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of 2,4,6-trisubstituted-1,3,5-triazines (2a-s) were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 19 compounds synthesized eight compounds showed MIC in the range of 1-2 microg/mL. These compounds are in vitro several times more active than cycloguanil. |
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