New vernocuminosides from the stem barks of Vernonia cumingiana Benth |
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| Authors: | Liu Jing Liu Yunbao Si Yikang Yu Shishan Qu Jing Xu Song Hu Youcai Ma Shuanggang |
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| Institution: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Beijing 100050, People's Republic of China. |
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| Abstract: | Seven new stigmastane-type steroidal glycosides, vernocuminosides A-G (1-7), have been isolated from the stem barks of Vernonia cumingiana Benth. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods including 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOE) experiments, especially the employment of Snatzke's method expressed by the induced circular dichroism spectra. Anti-inflammatory activities and cytotoxicities of compounds 1-7 were evaluated. |
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| Keywords: | Vernonia cumingiana Stigmastane Circular dichroism Anti-inflammatory activity |
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