Chronic inhibitory effects of two aminophenyl pyrrolidinediones on aromatase [Poster 11] |
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| Authors: | Mohammed H. Pourgholami Paul J. Nicholls H.John Smith Michael A. Shaw |
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| Affiliation: | Welsh School of Pharmacy, University of Wales Institute of Science and Technology, Cardiff, UK |
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| Abstract: | The aromatase-inhibiting effects of aminoglutethimide and of two aminophenyl-2, 5-pyrrolidinediones were studied in rats treated with pregnant mares' serum gonadotropin. All three compounds significantly inhibited ovarian aromatase activity and reduced plasma estradiol concentrations after 5 days of treatment. One of the aminophenyl pyrrolidinediones was less potent than the other two compounds, the IC50 values for inhibition of the aromatization of testosterone being 19.6 μM for aminoglutethimide and 21 and 63.1 μM for the aminophenyl pyrrolidinediones. |
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