首页 | 本学科首页   官方微博 | 高级检索  
     


Amino acid sequences of pilins from serologically distinct strains ofBacteroides nodosus
Authors:Neil M. McKern   David J. Stewart  Phillip M. Strike
Affiliation:(1) Division of Protein Chemistry, CSIRO, 3052 Parkville, Australia;(2) Division of Animal Health, CSIRO, 3052 Parkville, Australia
Abstract:Amino acid sequences of pilin from a strain of Bacteroides nodosus from serogroup B (234) and serogroup C (217) were determined. The amino-terminal N-methylphenlalanine residue of both proteins was followed by a hydrophobic sequence of 30 residues closely related to the N-terminal sequence of other pili having an amino-terminal residue of N-methylphenylalanine. These data lend support to the hypothesis that in pilins of this type, the amino-terminal sequence functions as a transport signal necessary for pilin to reach its external environment, as well as promoting intersubunit interactions for muintenance of the structural integrity of the pilus. Two hydrophilic hypervariable regions can be discerned across the pilin sequences, indicating possible locations of antigenic domains.
Keywords:Bacteroides nodosus  amino acid sequence  pilus  pilin
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号