Focal adhesions: structure and dynamics |
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Authors: | Petit V Thiery J P |
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Institution: | Subcellular structure and cellular dynamics, UMR 144, CNRS-institut Curie, Paris, France. |
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Abstract: | Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion. |
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Keywords: | focal adhesion integrins extracellular matrix Rho |
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