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cDNA Cloning of the Human Homologues of the MouseKe4andKe6Genes at the Centromeric End of the Human MHC Region |
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| Authors: | Asako Ando Yara Yukie Kikuti Atsuko Shigenari Hisako Kawata Naoaki Okamoto Takashi Shiina Lei Chen Toshimichi Ikemura Kuniya Abe Minoru Kimura Hidetoshi Inoko |
| Affiliation: | aDepartment of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259-11, Japan;bBiomedical Research Center, Olympus America Inc. 3 Technology Drive, East Setauket, New York, 11733;cDepartment of Developmental Genetics, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka, 411, Japan;dInstitute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, 4-24-1 Kuhonji, Kumamoto, 862, Japan |
| Abstract: | cDNA clones corresponding to theHKE4andHKE6genes at the centromeric end of the HLA region on human chromosome 6p21.3 were isolated and characterized. The predicted amino acid sequences of HKE4 and HKE6 exhibited 81.5 and 85.6% identity to the mouse homologues, Ke4 and Ke6, respectively.HKE4may encode a membrane protein with histidine-rich charge clusters. HKE6 possesses remarkable amino acid sequence conservation with several bacterial proteins with oxidoreductase function and also shows significant homology with the two unique functional domains containing the nucleotide cofactor binding site and the consensus motif characteristic of the members of the superfamily of short-chain alcohol dehydrogenases such as human and rat steroid and prostaglandin dehydrogenases. |
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